Playing "find the mouse pointer" is no fun for anyone with less than 20/20 vision, especially on laptops with super high-res screens. In this tip from Ed Bott, he tells you how to make the pointer easier to see.
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First, go to the Control Panel and choose Mouse Options.
On the Pointers tab, choose one of the Large or Extra Large schemes to make the pointer bigger.
While you're on the tab, select the "Display pointer trails" check box to make the pointer easier to see as it moves.
And at the bottom of that same tab, select the option that says "show location of pointer when I press the CTRL key." Which is really handy.
Click OK to save your changes and you're good to go.