Customize the [Windows]+E key shortcut to open what you want
Source: Greg Shultz
In this edition of the Windows Vista and Windows 7 Report, Greg Shultz shows you how to use AutoHotkey in Vista to re-route the [Windows]+E so that Windows Explorer opens a folder of your choice. He also provides you with a list of all of the standard [Windows] key shortcuts.
This download is also available as an entry in the TechRepublic Microsoft Windows Blog.