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http://spiceworks.com/

I ran across this here on TR and fell in love with it.
It offers help-tickets, hardware and software inventorying, network monitoring, reporting features, and alot more. Its great for tracking issues and is very customizable.

Just try it!

From their site:

* Automatic PC and software inventory and IT asset reporting to simplify your job.
* Network monitoring and troubleshooting to keep things running smoothly.
* An easy to use IT help desk for your company.
* IT answers, product reviews, and advice from SMB IT pros like you.