I use Malwarebytes at work on client's personal computers, it is the only program that gets rid of Vundo, none of the supposed tools work. For very bad infections where Malwarebytes won't install, I use the Avira Rescue System Disc, which runs off the disc, without the OS loaded, so that you can remove some of the junk before running a full Malwarebytes scan to get the rest. And of course, I delete files manually based on what the scan log files find.