Spyware Blaster uses host files and registry entries...
It would seem strange it would affect anything. I have seen competitors like older versions of PC-cillin choke on SpywareBlaster after updates, but I for the life of me couldn't understand why; unless it was a registry protection feature that had to run a review of each entry for approval. This may be why Spybot Search & Destroy won't list Spyware Blaster as a complimentary tool anymore - because Tea Timer gets confused by all the registry entries, and has to differentiate whether to load an alert on it or not.
I hadn't checked for a while and I didn't realize Patrick Kolla had written it for x64 already. However Adaware seems to supplant it now with the free adwatch function now available for customers. Most of the function and registry protection is as good as, and exceeds PepimK capablilities.
I have absolutely no trouble using both on Vista x64, they seem to compliment each other very well. My web pages load like lightning.