But hey, that's me. I'm the first to say use whatever you like best!

But I used ergonimic mice of varying types and prices for years and continued having wrist pain. Having used a Razer Copperhead for over a year, my pain has gone away. It was odd getting used to, but I like it so much I bought a second one for work. That's saying alot cause I'm a cheap sob!

The copperhead is of decent size, but it is more of a fingertip mouse and took some getting used to. The back of my palm rests on the mouse pad most of the time and I (unknowingly until recently) use my thumb and ring finger to control movement. Sounds awkward and ridiculous, but my wrist pain is gone. The mouse's really, really light weight may contribute. I hated that at first, but again I now love it so much I have two. Not to mention the pulsating blue logo screams uber geek.

On another note, I started going to the gym on a regular basis over a year ago or so when I bought my first copperhead, so that may well be a contributing factor as well. Either way, the mouse is comfortable and I've never been so fond of a piece of hardware that I bought a second one for workk. Most importantly, I have no wrist pain anymore and I'm satisfied.
Edit!!: I also messed up my wrists and broke a few metacarpal shafts in both hands so that may also skew my results a bit. It was a case of motorcycle vs Cadillac when I was younger, guess who got the short end of the deal!