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While I agree with your statement about relying on free anti-virus/anti-malware applications as a primary protection, I would be curious as to what you WOULD consider adequate. From my C|EH days, I recall using a number of tools that slide right past Symantec, AVG, Kapersky, and several others. One exploit still works against Symantec's Endpoint Protection 11 MR4.

I think the original article of 10 ways to detect malware is a valid one. However, if you begin the discussion of what provides total protection I believe you'll quickly come to the answer "none". Given enough time, resources and desire, I believe anyone can break into any system.