Used it off and on since Win98
I've used System Mechanic for years, on and off anyway. I think right now I use Vista Manager instead but not for any particular reason, in fact I don't run Vista Manager too often, I just used it to manually tweak a few settings.
As for Iolo's System Mechanic, I've always found that it gets better over time. Usually by the second or third optimization, it runs pretty slick.
In your case, I suspect that your system is probably in pretty good shape as is, which is why you didn't notice much with the regular system speed . As far as the Internet, deleting temp files and manually tweaking MTU settings usually tweaks better than the basic system management does, but I've found that less and less relevant with the newer releases of Windows. Sinc eusing Vista, I've pretty much stopped lookign for optimizers as mine really does run just fine.
If it gets buggy once a month or so, I'll reboot (which I don't normally do daily) and clean out temp files etc manually and run a registry cleaner but again I find Vista's process and HD management just fine for the most part, I find Vista's one of the better OS's to date, excluding Win7 as it's still a bit too new to tell yet. I certainly like it better than XP, by far and I think I've finally gotten over losing Win2KPro.