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Do this, and thats all you need. My regular maintenance consists of...

Antivir Anti-Virus - Scan Daily/Nightly
Malwarebytes - Monthly
Super Anti-Spyware - Monthly (Have it run at startup)
ATF Cleaner - Weekly to Bi-weekly
Uninstall Old Programs/One-Time Use Programs via Add/Remove Programs (Vista, 7 = "Programs and Features")
MyDefrag (used to be JKDefrag) - Monthly
Leaf Blower - Once a year/as needed
FSB = 800mhz or above - Move into the 21st Century (Speed saves time, Time = Money)
Check CPU, Hard Drive, and Case Temperatures every so often

Tips...
Don't use MS Tuneup Utilities like Disk Cleanup or defragger. (Use Third-Party apps)
Educate employees/family members about "safe surfing"
Throw Internet Explorer in the Trash (Firefox, Opera, or Chrome)
DON'T USE REGISTRY CLEANERS!!

I hope that helps someone out.