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I clean a lot of our networked pc's up from malware. The best course I have found so far is to use malwarebytes first, superanti-spyware second and if needed hijack this, though the first two have worked for about 97% of the issues. Fake AV problems have been the majority of issues. Occassionally I will have to boot to safe mode first to clean an infected pc. I do want to check out the A squared software though as I am always on the lookout for a new tool. We have also given up on adaware and spybot usually only finds cookies, in my experience.