Odd how I see folks at work and in cafes with the latest note/net book with a touchpad... and a mouse plugged in. I have worked with several touch screens on notebooks/tablets and standalone monitors, as well, as a dozen or more PDA/HPC/phone devices. I have found that the bigger the screen, the more fatiguing it is to use for any length of time. There are issues with support for the scribing hand (esp for us lefties), and for shoulders (and even backs) with all that reaching if we have any joint problems to begin with.

Our physical "configuration" and limitations dictate certain "classic" interface solutions such as keyboards and mice (although I prefer a trackball if I can find one with just the right layout, and durability, and/or a Trackpoint instead of touchpad when I am traveling mouseless).

To each their own.