if you spliced together dog genes with the intention of creating a dog the end result would be (hopefully) a dog. I imagine the same would go for a human.

Now if you combine the dog and human....you get Barf from spaceballs.

So I'd say the important pieces are the base materials and the intended design. Not so much the process, whether natural or artificial. I'm sure many people would be, unfortunately for the world, quick to make distinction between the two even if the distinction was minor or simply cosmetic.