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...on my 5-button (and 2-wheel!) mouse in the office. My 7-button mouse at home is configured similar way.

Combined with [Shift] or [Ctrl] buttons those buttons #4 and #5 are even more useful/powerful. In some programs (AutoCAD for example) [Shift]+[button 4] let me "copy with base point". It is A LOT quicker than typing "_copybase" followed by "Enter" and some more clicks...

Using modifiers [Shift], [Ctrl] or [Alt] - single or their combination - with various mouse buttons gives you even more flexibility than standard Windows (old or new) "standard" or "context sensitive" menus.

For "normal" user it may be seen as too complicated on the beginning, but once you learn them - using those shortcuts is automatic.

We musn't be afraid of using the keyboard TOGETHER with the mouse. Repetitive tasks are the best candidates to "build" them in mouse operation. Copy and Paste are probably the most frequently used actions performed on any PC."Delete" or "Erase" may be also popular commands, but I would not put them on my mouse...