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But GUI or not, I don't usually leave the keyboard unless I absolutely have to. It's a matter of efficiency. It might take a while to learn the keyboard shortcuts, but once you know them, you're saving time by using them.

The best example is office applications; you're wasting time if you don't know the standard keyboard shortcuts.

Which method of boldfacing is easier when typing a document?

Ctrl-B
type the word or phrase
Ctrl-B

OR
find mouse
find pointer
find Bold button
click button
find keyboard
type word or phrase
find mouse
find pointer
find Bold button
click button
go back to keyboard.

The same applies to print, underscore, cut, paste, copy, and many other commonly-used commands. I don't remember the last time I saw an office application for Win/Lin that does not use the standard Ctrl-[B/P/U/X/V/C] commands for these common functions.