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Also keep in mind that if you're going to use the Shadow Copies feature, you should use a 16K or larger cluster size. http://technet.microsoft.com/en-us/library/cc786349(WS.10).aspx

Unfortunately, I didn't follow best practices when I created a 2TB volume and eventually Shadow Copies started causing the volume to crash every day at the scheduled snapshot times. Took me a while to figure out it was Shadow Copy causing the problem.