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General System Speed Up
Always make sure ALL Applications are closed before clearing temp folders

Some places I check are:

C:\Windows\Temp folder -
Which doesn't always get emptied, and sometimes will contain files from ages ago which don't need to be there.

C:\Documents and Settings\ UserID \Local Settings\Temp folder -
Another place that may retain unnecessary files and folders which may collect over time and slow system.

C:\Documents and Settings\ UserID \Local Settings\Temporary Internet Files\Content.Word folder -
C:\Documents and Settings\ UserID \Local Settings\Temporary Internet Files\Content.Outlook folder -
C:\Documents and Settings\ UserID \Local Settings\Temporary Internet Files\Content.MSO folder -
These folders are usually cleared when clearing the cache in Internet Explorer, but you must be sure to specify that OFFLINE CONTENT (or files) be deleted as well.

Clearing the IE cache is probably one of the biggest things that gets neglected by users.

Posted by JonathanPDX
Updated - 28th Jul 2010