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Windows Defender? I've never known it find anything more after I've run AVG, MBAM, SuperAntispyware, SpyBot and Spyware Terminator. That lot usually cleans up, with CCleaner, often using Safe Mode for some of it.
But some times the nasties are more than usually stubborn. The variety of responses just confirms this - the variability of installations and users means we all need to be open-minded, and regularly read stuff like this to see what other people have found useful.
I've just downloaded Hitman Pro to add to my list of Weapons of Muck Destruction.