I've tried them all and although no one program catches everything, this comes the closest. Minimal learning curve, Updates fast. Few false positives. It's the one I run with. As cross-checks, I use (but do NOT run as resident/background): HitManPro (cloud), Emsisoft, Malwarebytes, SuperAntiSpyware. Gave up on MSSE because Windows Security Center wouldn't recognize it -- but that was an earlier version & I know many love it now.