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...as well as for dozens of clients. My personal backup is 250GB (off of a domain controller no less) and it has been extremely reliable. Over the years I have experienced a few hicups with clients that required a re-install which always solved the problem. Fortunately after a few days with no backup, you get an e-mail message alerting you to a potential problem. (I do wish that alert period was user-adjustable down to 24 hours, or some period between)

Yes, if you are an "IT professional" working in an environment with full-time support and substantial infrastructure and capability to engineer your own off-site solution, Carbonite is going to seem slow and inadequate. Most SMBs and individual users do not have those kind of resources, and nobody does for a mere $59/year.