I think that for seeing "where's all my disk space gone", SequoiaView from the University of Eindhoven has to rank pretty highly.
If this article were more than a thinly-veiled ad for Microsoft products and some proper research had been done, I'd've expected to see more innovative and unusual ways to view your data such as this.
Website:
http://w3.win.tue.nl/nl/onderzoek/onderzoek_informatica/visualization/sequoiaview//