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Plays well with other antimalware but not with other AV products. No AV really plays well with other AV products though. It is light on system resources. I have used it with MalwareBytes, Spybot S&D, ClamWin(I keep it on a thumbstick for secondary virus scanning) and a number of other antispyware or antimalware products.

I wouldn't go so far as to claim that other AV companies can't cope anymore, but MSSE is a solid offering and holds its' own in the various tests I have seen.

Personally I use Avast/Malwarebytes/Spybot for my own PCs and recommend them to anyone who asks my opinion.