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Where's the poll option for,
"It doesn't matter to me one way or the other."

The confusing 'Office logo' button in the original 2007 version of the ribbon was our biggest problem. Once I located the 'Save' and 'Print' functions, my less-than-technically-advanced users didn't have much trouble making the transition. Fortunately, that button was replaced with a proper tab in the 2010 version. Customizing the QAT is no harder than building a custom toolbar in previous versions.
Updated - 11th Nov 2011