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I once had a misfortune of attending a presentation dressed to kill, as it were.
Backgrounds were dark purple, text was bright orange and/or fluorescent yellow. While contrast was there all right, this had the effect of making your eyes water after 10 seconds, bleed after 20, and trickle down your cheeks after 30. NEVER AGAIN.
(not to mention that handouts were pretty damn illegible). Urgh.