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My experience is that whilst newer (faster) computers may see little gain from running a registry cleaner or defragging, there are a lot of older and slower computers that do benefit from both. If I do reccomend / use a Registry cleaner then I generally use CCleaner because, as noted, it is a low risk cleaner and does a backup by default (my experience with it is very good). On the strength of the article I think I will give Comodo a try - in a careful way of course :- )