depends on the company and culture
my company culture is very family-friendly - on-call is rotated and people rarely work > 40 or 45 hrs / week. That said, the pay isn't as high as other places. You might have to put up with being on-call more, work longer hours when you first start out. I did, but I had no IT college work, just built my career on experience. Had to put in my dues, so to speak.