Always open your hotel room door all the way so no one can be behind it, and waiting for you! Then listen, is there anyone in the bathroom, open that door all the way.
Do not travel late at night....after 10PM. Going out drinking with several women and returning to your hotel loud and obnoxious advertises your defenselessness.
I am techie who is also a hotel night auditor (11pm to 7am).
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