The only big thing I'd call out, is to locate the WSUS data store on a separate drive that can be easily upgraded (it can get BIG) and has nothing else on it, to NOT back that up (it's all data that can be re-downloaded if needed, why waste a ton of backup drive/tape space?), and to make sure you ONLY download the languages that you need (ie: if you only use English versions of Windows, no need for patches in Chinese, Hungarian, French, etc.), that can waste a ton of space.

J.Ja