On Vista or better systems I prefer Komodo over CCleaner. I think it does a more thorough registry clean. On Win XP it can cause odd behavior (if monitoring is turned on) and even brick a PC if you use the advanced registry clean option.
Also, do not use a defragger at all if you have an SSD drive. It will significantly reduce its life expectancy.
Can you explain why it will significantly reduce its life expectancy?
Just my guess. I suppose that scheduled (i mean often) defrag of SSD media was bad idea. They have less rewrite cycles compared to HDD, and actually doesn't read faster after defrag, because they not affected by search/positioning time as HDD one.
The "cells" used to store data are said to be rated for a certain number of writes/deletes/rewrites that are low enough to be affected by frequent defrags. I haven't researched this, so don't know whether it's a problem or not.
CCleaner is a must, especially if you fail to clean various browser caches. I back up its registry cleaner with Glary Utilites and then run the Glary registry defrag. I was a devoted fan of Defraggler, but the latest release has issues with the app's service continuing to run after use and then it sits there using up resources until it cause a system bog down or crash. So I have switch to IObit's Smart Defrag v2. Be sure to use the Boot Time Defrag to get the system files defragged.
I would substitute SIW (System Information for Windows) for Belarc Advisor. Also free, and more comprehensive.
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