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If you use the iPad for drawing then it's worth splashing out 10-quid or so for an iPad specific stylus. Pens, or a stylus for other devices won't work.

Also, getting a sturdy case is well worth the investment! IMHO you need a case that covers the front AND the back, not those flimsy flip-over ones that get given away free in a lot of mobile phone shops. And a quick warning - if you want to use apps which take advantage of the built-in compass, avoid a case with magnets.

Lastly, if you're not using wifi or bluetooth at that moment in time, switch it off to save battery life.