Ahem! They(iObit) are in court for stealing source code from MalwareBytes!! You gonna trust that Chinese company with your intellectual property? Good luck!
You can't have a proper defense without a blended one - no one solution is going to save you, and against the threats featured in this article, probably none will save you. Only new or different hardware, or a very severe drive lock program like Drive Vaccine will even come close.
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