Recently had a customer's machine that using any browser (IE, Firefox, Chrome) had constant popups and redirects. Tried the usual list of free products (Malwarebytes, Superantispyware, TDSSkiller, Sophos, OT, Combofix, etc) and nothing solved the problem. A friend recommended Spyhunter (not free), and in desperation I hunted down a discounted copy of it and tried it. So far, it seems to have solved the problem. Sometimes I find that their never seems to be any one or two products that solve problems, but about ten products you need at your disposal to handle most situations.