my son has used it in his system without any issues, but neither has run it in a VM, only as a Live CD or an install. He has an i7 system and I've used a number of i5 and P4 systems.

Depending on what you're running it on, it could be the VM or the base software - Linux uses Industry Standard command sets, while Windows does not, so not sure how well the VM software will handle that type of low level hardware hand off as I don't use VMs too often.