For me, crashes that are hardware related are rare, usually the crash is from a bug in the game, usually during a save.
But other issues like, if anything modifies breezehome, then hearthfire causes your game to crash when you try to enter breezehome. Or if you try to save during the mission in that tower where you sent back in time after drinking that potion, the one to fix everyones dream problems. If you save after drinking the potion, your game will crash, but even the end of mission auto save will cause it, so you have to disable all auto saving as well.
My steam page if your interested.
I'm currently working through Super Skyrim Bros.
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