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I set up the following catgories of programs and apps on my start screen.
(in order left to right / with left most = most frequently used)
Home: Desktop, Google, IE, The Time, Calendar Store
Communication: Outlook, Mail, People, Messaging
Office: Office suite, Evernote, Adobe Acrobat, PDF Touch, SkyDrive
Tools: Remote Desktop, Metro Commander, Control Panel
Entertainment: Multimedia 8, Tunein, & Magazines
This works for me.
What I wish Windows 8 could do is search by category & change the focus to that category. My categories are manageble - spanning two screens but if you have many many programs, it would be helpful to search for categories.
Nested categories would be useful too.
Also, zooming in on the start screen minimizes the icons and you can select a category this way.
All that being said, I usually know at least part of the name of the program I am looking for so typing it in to open it is very quick.