I have "unsubscribed"...
From a few newsletter/advertisers - but then they were previously approved sources. A good rule of thumb, is to read the unsubscribe link at the bottom of each e-mail to see if it explains why you are getting it in the first place. If they are actually legit, the explanation will help rattle the memory for why there is a subscription.
Many times I've wanted to unsubscribe from Cisco's emails - but I know I've been getting them every since I took my CCNA, so I put up with it. However, I thought everyone knew not to click "unsubscribe" to an illegitimate email spammer. That bit of advice has been around a while.
I wish the author all the happiness in the world, it is always makes me pause to reflect when they leave the TR fold.