GAMESS User's Guide:
'A wide range of quantum chemical computations are
possible using GAMESS...
By 2005, GAMESS had grown to roughly 650,000 lines of
FORTRAN.'

That was the situation 8 years ago and of course the application, which dates from the 1970 is still being developed. They did, at one point, move from FORTRAN 66 to 77.

Of course, there are dozens of other major applications like that, and you'll be running some of them yourself if you're connected to Boinc (perhaps via Facebook's Progress Thru Processors). Incidentally, please note this advert for charitable work that costs contributors almost nothing.

Back to the fundamentals, people shouldn't be asked to commit their life's research work or their business affairs to cloudy platforms with a life expectancy of 3 years.