I've been using this for years
About 8 years ago I got a nasty trojan via a data CD that was a back up for my team's work at our office. At the time I was running on of the better(?) commercial AV programs on my PC. The commercial AV never detected it but I knew something was wrong with my PC because a lot of very strange things started to happen, especially with IE. So I loaded up a one of the better freeware AV programs and still nothing. To make a very long story short, I eventually found Malwarebytes on the net via my work computer (because my home computer would only take me where the trojan wanted me to go on the internet, it didn't matter if I was using IE or Firefox). I took it home installed it and it found the trojan deleted it and on reboot cleaned it out completely. The first place I went after reboot was the Malwarebytes site and bought the program. I've change AV programs a couple of times since then but I always load malwarebytes and have it running, always.
It is one of the essential programs you must have in your toolbox.