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Never had a problem using CD/Dvd while in Safe Mode (withOut Networking). Sometimes needed to run an Install CD to fix a problem. I just tested; I believe I had no Usb problems, before, but to make sure.. I re-booted, into Safe-mode (NO Networking), and loaded a Flash stick, with no problems.
BitDefender Removal Tool would NOT work in Safe Mode (Networked or Not). Specifically Said it had to run from Normal Boot. Tried off Usb stick and internal Hd.
Kaspersky TDSSKiller worked from Safe-Mode (Networked and Not).