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If your Twitter account is 100%, and I don't mean 99.9% business related it MAY help. But if your personal interests intermix in your business tweets, I see it only hurting. Even then, some HR professionals are reading 100 resumes an hour, I don't see them taking the time to decipher tweet-speak.

Now, for certain individuals, I can see it as a benefit. If you are in advertizing or a looking to run someone's social media presence, for example.