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I was sure that this one would be in the top 10 but it wasn't, so here it is:

If, like many, you are often watching your keyboard when you type rather than the screen, then you've often typed a line or two after having forgotten to cancel the Caps Lock. Rather than re-type, you can reverse the process easily by selecting the text and using Shift F3 repeatedly until you achieve the desired result.

Try it, it's magic. It's even worth copying such mis-formatted text from an email to Word in order to correct it, and then back, rather than re-typing which, while not taking too much time, is extremely irritating.