We have used 80 gb HD in removalble drawers as a backup solution for a few years for small business servers. Run the script to Xcopy the requested files, shut down the machine and swap the drive. fire it back up.
recently we set up a hot swapable removable drawer using serial ata technology. The drawers are cushioned, and if you have 3 drives you have one on site: one at home one on the machine. If you want to use image technology you can. Drive is much more reliable than tape.