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Lotus Notes:SMTP Protocol Returned a Permanent Error 550 5.7.1 Unable to re

I have a Lotus Domino 7 server.The mails sent out to internal accounts are being delivered but mail sent out to external accounts are not getting delivered.The Lotus Domino 7 server stopped sending outgoing mails to external account and started reporting this error: Error transferring to 10.108.45.35;SMTP Protocol Returned a Permanent Error 550 5.7.1 Unable to re.Nothing was changed on the server but this suddenly started occuring. All the outgoing messages are being held in the mail.box file and aren't being delivered. Any ideas what could be causing this and how to resolve it? .
1st Nov

Clarifications

someone pls help me as soon as possible

Answers (3)

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SMTP Error
What happens when you create a new Mail.box? Does mail flow continue?
1st Nov

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no i haven't created any mail.box
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I believe that a mail relay error
Could be that your external ip has been flagged as a spammer. You may want to contact your ISP to help resolve.
1st Nov

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ya that is mail relay error and can you make me it more clear please because i am new to Lotus Domino server.
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