Try Booting without the Mouse to see if you have access. What type of Mouse is it Logitech, if it is try uninstalling Logitech Setpoint.
Go to your device manager find the Mouse and uninstall the driver. Then reinstall with the correct one (or let windows use the generic (default) driver. Restart the PC when you have made these changes.
Try another mouse.
Try Reliability Monitor again.
Basic Keyboard shortcuts to enable you to move around.
Press this key
To do this
CTRL+C
Copy the selected item
CTRL+X
Cut the selected item
CTRL+V
Paste the selected item
CTRL+Z
Undo an action
DELETE
Delete the selected item and move it to the Recycle Bin
SHIFT+DELETE
Delete the selected item without moving it to the Recycle Bin first
F2
Rename the selected item
CTRL+RIGHT ARROW
Move the cursor to the beginning of the next word
CTRL+LEFT ARROW
Move the cursor to the beginning of the previous word
CTRL+DOWN ARROW
Move the cursor to the beginning of the next paragraph
CTRL+UP ARROW
Move the cursor to the beginning of the previous paragraph
CTRL+SHIFT with an arrow key
Select a block of text
SHIFT with any arrow key
Select more than one item in a window or on the desktop, or select text within a document
CTRL+A
Select all items in a document or window
F3
Search for a file or folder
ALT+ENTER
Display properties for the selected item
ALT+F4
Close the active item, or exit the active program
ALT+SPACEBAR
Open the shortcut menu for the active window
CTRL+F4
Close the active document (in programs that allow you to have multiple documents open simultaneously)
ALT+TAB
Switch between open items
CTRL+ALT+TAB
Use the arrow keys to switch between open items
Windows logo key +TAB
Cycle through programs on the taskbar by using Windows Flip 3-D
CTRL+Windows logo key +TAB
Use the arrow keys to cycle through programs on the taskbar by using Windows Flip 3-D
ALT+ESC
Cycle through items in the order in which they were opened
F6
Cycle through screen elements in a window or on the desktop
F4
Display the Address bar list in Windows Explorer
SHIFT+F10
Display the shortcut menu for the selected item
CTRL+ESC
Open the Start menu
ALT+underlined letter
Display the corresponding menu
ALT+underlined letter
Perform the menu command (or other underlined command)
F10
Activate the menu bar in the active program
RIGHT ARROW
Open the next menu to the right, or open a submenu
LEFT ARROW
Open the next menu to the left, or close a submenu
F5
Refresh the active window
ALT+UP ARROW
View the folder one level up in Windows Explorer
ESC
Cancel the current task
CTRL+SHIFT+ESC
Open Task Manager
SHIFT when you insert a CD
Prevent the CD from automatically playing
Control the mouse pointer with the keyboard (Mouse Keys)
http://www.microsoft.com/enable/training/windowsvista/mousekeys.aspx