Answer for:

HDD not recognized after changing drive Letter

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Is it USB or eSATA or something else ?

On power up does the drive spin up and do the usual few seconds of activity ?

Is the use of conflicting with a CD/DVD/Blueray drive or chip reader or something.

On the Win 7 system...
Disconnect the problem disk and reboot
Is some device assigned to ?
Be sure to look through the lower pane list. CD, DVD etc appear only there.
If there is a then change it to some other letter.
Connect the problem drive. Is it visible at all in DISKMGMT.MSC

Try a power cycle reboot.