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How to remove a virus that blocks access to files and programs?

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ComputerCookie

you should be able to turn off system restore, restart in safe mode with networking update your AV and run a scan to remove the virus. If it's a more complex trojans you may need to edit startup using msconfig to remove any trojans and restart the system in safe mode, download Spybot S&D and restart in normal and install downloaded files and run, do not attampt to access the internet intil the trojans are removed.

if you need more precise instructions post back to this question.