+ 0 Votes Limited Information TheChas December 31, 2012 at 3:31am PST Well, the cards I looked at did not specify that they could not be used with optical drives. But, neither did they specify that they work with optical drives. As most of the plug-in SATA cards are designed for use in setting up RAID arrays, they would not be tested with optical drives. The only 4 port SATA card I found that might work is the High Point Rocket 640. This will work best in a 4X PCIe slot. Most of the other 4 port cards that I did find are designed for a server application and may only support hard drives. Chas + 0 Votes Reponse To Answer newjughead December 31, 2012 at 6:44am PST Thanks Chas! I'll try that one.