+ 0 Votes Actual mileage may vary robo_dev 3 years ago I've never seen any damage that cannot be undone with respect to startup programs. The worst case would be that you would need to reinstall an application. It's rare that a Windows application would use win.ini, that is a holdover from Windows 3.0. + 0 Votes Don't need Kenone 3 years ago To turn off disk indexing open "My Computer" right click on the drive, click "Properties", at the bottom of that screen you can disable indexing for that drive. If you turn it off on all the drives you can shut down the indexing service in "Services" You don't need any of those things in Scheduled tasks. If the Windows Genuine Advantage puts itself back google WGA Setup and follow those instructions for getting rid of it, can be a problem. As for win.ini I wouldn't touch anything that says "extensions" or "Intel". Fonts? that's up to you, what do you use the machine for? If you use a bunch of fonts you might want to go into the "Fonts" directory and thin out the herd. + 0 Votes Start Up Items PuterGuy07 3 years ago Most programs that load at Windows startup are not necessary, but rather are "helper" programs that either go out and automatically check for updates at predetermined intervals, or "listen" or wait for certain events to happen in order to spring to life. What they don't tell you is that a majority of these programs will load automatically if you start the dependent program, and usually won't take any longer than if they were loaded at startup. These programs slow windows down tremendously because they go out and check for updates every single time Windows boots. I put all of them into batch files and execute the batch files using Windows task scheduler about once a month during a lunch hour or some other off time. I also turn off Windows disk indexing if it is an XP system. This doesn't really work as intended in XP, and causes needless disk activity which slows things to a crawl in XP. They seemed to have fixed it in Windows 7. Hope that helps you.