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Use USB stick as extra permanent storage.

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For most programs you cannot just copy them to another drive and have them run.

There are so many pointers and registry settings that it is best to uninstall and then reinstall the program.

I would also STRONGLY recommend that you have an additional backup of ANY file that you store on a USB (or any other flash) drive. Any number of glitches can cause a flash drive to loose pointers to files or even the file structure.

As stated, the USB drive will slow down your system. Even more so if this is older hardware and has USB 1 rather than USB 2 ports.