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Virtual Desktops

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Your question is somewhat unclear.
If you need VPN-access there's always the built in functionality of RRAS in Windows Server 2008 and a lot of 3rd party products.
If you need to secure your clients you could always use bit locker if you run Windows Vista, combined with a server/domain-isolation with a NAP-solution you could ensure that only approved clients can connect to your servers. Protection against viruses and malware could be provided by any 3rd-party product or Windows Defender / Forefront client security.