If your e-mails are tightly related to your projects, EverDesk Optima is designed for you. Users who are willing to spend the time needed to learn to use its feature set will be able to leverage it well. It has some functionality that is very innovative in the e-mail management space.
While on the surface, the user interface resembles Microsoft Outlook, a closer look reveals the differences. For one thing, the folder list on the left is not my list of email folders, but the contents of "My Documents." For another thing, some of the items in the list are not emails, but files.
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